Nullary
Negative results intelligence for drug discovery — query measured failures via MCP.
Connect it
Settings → Connectors → Add custom connector
URL: https://mcp.nullary.ai/mcpSettings → Apps & Connectors → Advanced → Developer mode
Create connector with URL: https://mcp.nullary.ai/mcp{
"mcpServers": {
"nullary": {
"url": "https://mcp.nullary.ai/mcp"
}
}
}claude mcp add --transport http nullary https://mcp.nullary.ai/mcp{
"servers": {
"nullary": {
"type": "http",
"url": "https://mcp.nullary.ai/mcp"
}
}
}35 tools, verified live
search_inactive_compoundsread-onlyInactive small-molecule compound-target pairs.
search_failed_selectivityread-onlySmall molecules that failed selectivity.
search_admet_failuresread-onlySmall-molecule ADMET failures.
search_failed_guidesread-onlyFailed/ineffective CRISPR guides.
search_failed_essentiality_screensread-onlyNon-dependency / failed essentiality screens.
search_ancestry_specific_failuresread-onlyAncestry-specific CRISPR failures.
search_developability_failuresread-onlyAntibody developability failures.
search_failed_clinical_antibodiesread-onlyDiscontinued/terminated clinical antibodies.
search_failed_peptide_therapeuticsread-onlyFailed peptide therapeutics.
search_peptide_stability_issuesread-onlyPeptide stability/half-life failures.
search_failed_protacsread-onlyPROTACs that failed degradation/ternary/permeability.
search_protac_e3_issuesread-onlyPROTAC E3-ligase recruitment / ternary failures.
search_failed_oligonucleotidesread-onlyASOs/siRNAs that failed engagement/developability.
search_oligo_delivery_failuresread-onlyOligonucleotide delivery failures.
search_failed_vaccinesread-onlyFailed/terminated vaccines (by pathogen/indication).
search_vaccine_immunogenicity_failuresread-onlyFailed vaccine immunogen designs.
search_failed_adcsread-onlyADCs that failed at any stage.
search_adc_linker_failuresread-onlyADC failures attributed to linker chemistry.
search_failed_bispecificsread-onlyBispecifics that failed at any stage.
search_bispecific_format_failuresread-onlyBispecific format/engineering failures.
search_admet_failures_all_modalitiesread-onlyADMET failures across ALL modalities.
search_drug_drug_interaction_failuresread-onlyDrug-drug interaction failures.
search_mechanism_failuresread-onlyApproaches that failed for a mechanism (by target).
search_failed_replicationsread-onlyFindings that failed to replicate.
search_safety_failuresread-onlyClinical/preclinical safety failures across modalities.
search_target_historyread-onlyALL failed approaches against a target across every modality.
search_indication_historyread-onlyALL failed approaches for an indication across every modality.
search_pathogen_historyread-onlyVaccine + antimicrobial + antibody failures for a pathogen.
get_compoundread-onlyA compound (structure, name, max clinical phase) + its full negative profile across modalities/sources.
get_finding_provenanceread-onlyFull provenance + detail for a single finding by id.
get_target_landscaperead-onlyTarget 'graveyard' / exhaustion index: how many distinct compounds/agents have been tried against a target and failed, broken down by modality and outcome. Answers 'how picked-over is this target?'. Accepts a gene symbol (e.g. EGFR) or a UniProt accession (e.g. P00533).
list_top_targetsread-onlyCoverage browse: the most heavily-pursued ('graveyard') targets, ranked by recorded negative findings. Optional family filter (kinase, gpcr, protease, nuclear_receptor, ion_channel, transporter, phosphatase, other).
list_modelsread-onlySummary of the Layer-1 inactivity-scoring model registry: how many per-target models, split by family, and median scaffold-split ROC-AUC.
get_model_cardread-onlyPer-target Layer-1 model card: training counts and held-out scaffold-split metrics (ROC-AUC, PR-AUC, Brier, calibration). Accepts a gene symbol (e.g. EGFR) or UniProt accession (e.g. P00533).
get_coverageread-onlyPer-modality and per-source coverage stats (honest Phase-1 numbers).
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